Highlights the importance and benefit of mass spectrometry-based metabolomics for identifying biomarkers that accurately screen for potential biomarkers of diseases Mass spectrometry-based metabolomics offer new opportunities for biomarker discovery in complex diseases and may provide pathological understanding of diseases beyond traditional technologies. It is the systematic analysis of low-molecular-weight metabolites in biological samples and has been applied to discovering and identifying the perturbed pathways. Currently, mass spectrometry-based metabolomics has become an important tool in clinical research and the diagnosis of human disease. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines comprehensively presents the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics such as metabolites analysis, biomarker discovery, technical challenges, discovery of natural product, mechanism interpretation of action, discovery of active ingredients, clinical application and precision medicine, and enhancing their biomedical value in a real world of biomedicine, shedding light on the potential for spectrometry-based metabolomics. It highlights the value of mass spectrometry-based metabolomics and metabolism to address the complexity of herbal medicines in systems pharmacology, especially, to link phytochemical analysis with the assessment of pharmacological effect and therapeutic potential. Each chapter has been laid out with introduction, method, up-to-date literature, identification of biomarker, and applications Covers the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics in the discovery of biomarker, active ingredients, natural product, etc. Constitutes a unique and indispensable practical guide for any phytochemistry or related laboratory, and provides hands-on description of new techniques Provides a guide for new practitioners of pharmacologists, pharmacological scholars, drug developers, botanist, researchers of traditional medicines. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines provides a landmark of mass spectrometry-based metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all biomedical science fields.

Discusses how to solve real world problems in drug metabolism using mass spectrometry.

Das E-Book Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines wird angeboten von Wiley-VCH GmbH und wurde mit folgenden Begriffen kategorisiert:
Biowissenschaften, Chemie, Chemistry, Genomforschung u. Proteomik, Genomics & Proteomics, Life Sciences, Mass Spectrometry, Massenspektrometrie, Metabolomics, Metabolomik, Pharmaceutical & Medicinal Chemistry, Pharmakologie, Pharmazeutische u. Medizinische Chemie

Chapter 1: Current state of the art of high-throughput metabolomicsChapter 2: Innovations in analytical techniques of metabolomicsChapter 3: Sample preparation method for mass spectrometry-based metabolomicsChapter 4: Multivariate data analysis approach for mass spectrometry-based metabolomicsChapter 5: Mass spectrometry-driven metabolomics for metabolites and metabolic pathway analysisChapter 6: Metabolomics as drivers for biomarker discovery and mechanism interpretationChapter 7: Current status of technical challenges in mass spectrometry-driven metabolomicsChapter 8: The application of metabolomics in cancer managementChapter 9: Metabolomics in coronary heart disease: From biomarker identification to pathomechanism insightsChapter 10: Metabolomics applications in neurological diseaseChapter 11: Metabolomics towards precision medicineChapter 12: Mass spectrometry-based metabolomics towards biological function analysisChapter 13: Mass spectrometry-driven active ingredients discovery from herbal medicineChapter 14: Metabolomics application in herbal medicineChapter 15: Mass spectrometry-based metabolomics insights into the mode of action of natural productsChapter 16: Mass spectrometry-driven lipidomics for biomarker, molecular mechanism and therapyChapter 17: Potential application of mass spectrometry-based lipidomics for herbal medicine