The third volume of the "e;Practice of Intramedullary Locked Nails"e; places a special focus on recent advancements in understanding the biology of fracture healing of long bones, the emerging technologies that further enhance the minimally invasive nature of closed treatment of fractures, and the availability of various surgical techniques in intramedullary fixation. The application of new technology in prevention of infection and application of the intramedullary fixation of fractures in pediatric and adolescent patients are also described. The contributors to this volume are from different well-known trauma centers and are pioneer surgeons in the development and practice of intramedullary locked nails.

Advances in Biology and Fracture Healing in Locked Nails.- Cellular Aspects of Bone Defect Healing After Implantation of Calcium Phosphate-Based Bone Substitutes.- Osteoinduction: Basic Principles and Developments.- Intramedullary Reaming of Long Bones.- Differentiation Capacity and Characterisation of Cells Growing out of Human Reaming Debris.- Materials Used for Intramedullary Devices.- Implant Alloys and Interfacial Engineering.- New Designs of Intramedullary Nails.- A New Titanium Nail for the Femur: Concept and Design.- Advances in Tibial Nailing.- The Development of Retrograde Nailing for Distal Femur Fractures.- Retrograde Nailing of the Femur: Contemporary Indications and Technique.- Antegrade Femoral Nailing Without the Aid of a Fracture Table.- The Operative Technique for the Latest Generation Gamma Nail (the Gamma3).- Evolution of Implants for Trochanteric Fracture Fixation: The Engineer’s Point of View.- A New Concept in the Treatment of Fibular Fractures with Intramedullary Implants.- Hydraulically Expandable Nailing in the Treatment of Long Bone Fractures and Pseudarthroses.- Proximal Humeral Fractures.- Intramedullary Nailing of Proximal Humeral Fractures.- Intramedullary Nailing of Humeral Shaft Fractures.- A Fully Implantable, Programmable Distraction Nail (Fitbone) — New Perspectives for Corrective and Reconstructive Limb Surgery.- A Novel Internal Callus Distraction System.- Callus Distraction with the Albizzia Nail.- Intramedullary Fixation of Long Bond Fractures in Infancy and Adolescence.- Intramedullary Stabilization of the Long Bones in Children with Osteogenesis Imperfecta.- Intramedullary Fixation of Long Bone Fractures in Infancy and Adolescence.- New Technologies: Navigation and Targeting Devices.- Basic Principles of Fluoro-Navigation.-New Technology: Image-Guided Navigation in Orthopaedic Trauma Surgeries.- Review of Existing, Mounted Targeting Devices for Distal Locking of Intramedullary Nails.- Distal Locking with Mechanical Jig (Author’s Own Technique).- Coating of Implants and Infection Prophylaxis.- Rationale for Antibiotic Prophylaxis in Open Fractures.- Active Coating of Implants used in Orthopedic Surgery.- Plasma Polymer — High-Porosity Silver Composite Coating for Infection Prophylaxis in Intramedullary Nailing.