This book contains all refereed papers that were accepted to the third edition of the Complex Systems Design & Management (CSD&M 2012) international conference that took place in Paris (France) from December 12-14, 2012.(Website: csdm2012.csdm.fr) These proceedings cover the most recent trends in the emerging field of complex systems sciences & practices from an industrial and academic perspective, including the main industrial domains (transport, defense & security, electronics, energy & environment, e-services), scientific & technical topics (systems fundamentals, systems architecture& engineering, systems metrics & quality, systemic tools) and system types (transportation systems, embedded systems, software & information systems, systems of systems, artificial ecosystems).The CSD&M 2012 conference is organized under the guidance of the CESAMES non-profit organization (cesames.net).

Engineering Cyber-Physical Systems: Challenges and Foundations.- Game-Theoretical and Evolutionary Simulation: A Toolbox for Complex Enterprise Problems Architecting Complex Systems in new domains and problems: Making sense of complexity and managing its unintended consequences.- Agility Problems in Traditional Systems Engineering - A Case Study.- Modeling transportation systems: a case study with the open method Praxeme.- PBS : a major enabler for Systems Engineering - A thematic thinking by Thales Systèmes AéroportésFIT.- Requirement management for complex systems, a critical element of the integration process.- Modelling languages for Functional Analysis put to the test of real life Jean-Luc Voirin.- Modeling the impact of requirements change in the design of complex systems.- Model-Driven Development of Logistic Systems using Domain-Specific Tooling.- Smart Grid: Constructing a System of Systems Model Using Both Qualitative and Quantitative Assessments.- Prototyping Systems Thinking Curriculum Development for Pre-College Students.- An Integrated Approach to Developing Automotive Climate Control Systems.- Flexible Product Line Derivation applied to a Model Based Systems Engineering proces.- Towards an Architectural Design Framework for Automotive Systems Development.- Human emotional interaction and hydrotherpy.- Industrial design keys Synchronisation phenomena in electrical systems: emergent oscillation in a.- Orchestrating situation awareness and authority in complex socio-technical systems.- A Collaborative Distributed Control and Building Performance Simulation based on Systems Engineering Practice.- An Organizing Taxonomy of Procedures to Design and Manage Complex Systems for Uncertainty and Flexibility.