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Chalcone based sulfonohydrazides as possible antimicrobial agents
3,4-Dimethoxybenzaldehyde, 4,5-Dimethoxy-2-[3-oxo-3-phenylprop-1-en-1-yl]benzene Sulfonic Acid Derivatives
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Gewicht:
113 g
Format:
220x150x4 mm
Beschreibung:
Muhammad Athar Abbasi (Assoc. Prof., GCU Lahore) is HEC approved supervisor. He is a recipient of Research Productivity Award from 2008-14 from PCST, Pakistan. He has authored 141 research papers.Sabahat Zahra Siddiqui (Asst. Prof., GCU Lahore) has authored 40 research publications. She worked as a research scholar at University of Pennsylvania.
A series of potential biologically active 4,5-dimethoxy-2-[3-oxo-3-phenylprop-1-en-1-yl]benzenesulfonamides was synthesized. 3,4-Dimethoxybenzaldehyde was condensed with acetophenone followed by its chlorosulfonation to get 4,5-dimethoxy-2-[3-oxo-3-phenylprop-1-en-1-yl]benzenesulfonyl chloride, which was further reacted with a number of amines and hydrazides to get the 4,5-dimethoxy-2-[3-oxo-3-phenylprop-1-en-1-yl]benzenesulfonic acid derivatives. All the synthesized compounds were subjected to preliminary evaluation for their antibacterial activity against selected strains of gram positive and gram negative bacteria. Some of the assayed compounds showed marked activity.