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Green Synthesis of 2-Amino-4-Arylthiazoles Employing MWI and Water
Efficient and Rapid Synthesis
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Format:
220x150x0 mm
Beschreibung:
Dr. Kishor S. Jain, M. Pharm., Ph.D., F.I.C., is Professor(PG-Research) at Sinhgad Institute of Pharm. Sci.,Lonavala, Pune, India. Mr. Gajanan S. Wankhede M. Pharm., and Mr. Kunal K. Jain B. Tech.(Biotech.) worked for this project with Dr. Jain.
A green chemical synthetic protocol has been developed for the rapid parallel synthesis of a library of biologically potential 2-amino-4-arylthiazoles, employing water as a solvent under microwave irradiation (MWI). This novel process yields the target NCE s in very short time, good yield and purity. The judicious use of water as green solvent is attractive and cost effective & makes the process eco-friendly. Besides the general discussion on the biology and synthesis of 2-aminothiazoles, a short review on MWI and use of water as a green solvent is also included. The target NCE s bear good antifungal and antibacterial potential.