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Advances in Anti-Inflammatory Drug Research
Various efforts made towards the development of anti-inflammatory drugs
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Gewicht:
125 g
Format:
220x150x5 mm
Beschreibung:
Dr. Atul Bhardwaj born in Punjab India and had his schooling in Batala. He obtained B.Sc. (Hons) and M.Sc. (Hons) in Chemistry followed by PhD. in Synthetic Organic & Medicinal Chemistry at G.N.D.U. Amritsar. He worked as Project Scientist at IIT Kanpur. Presently, working as Postdoctoral researcher (Drug discovery) at University of Alberta, Canada
This book is focused on the development of non-steroidal anti-inflammatory drugs (NSAIDs); the biological target of these drugs is cyclooxygenase (COX) enzyme, which exists in two closely related isoforms viz. COX-1and COX-2. Based on the housekeeping functions of COX-1isoform and pathophysiological roles COX-2 isoform, the selective inhibition of COX-2 is desirable. NSAIDs like aspirin, ibuprofen, indomethacin, diclofenac, celecoxib, rofecoxib etc. exert their anti-inflammatory effects through the selective/non-selective inhibition of COX-1and/or COX-2 enzymes.