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Transdermal Patch of Lamivudine and Stavudine-Loaded Ethosomes
For The Treatment of AIDS
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Gewicht:
102 g
Format:
220x150x4 mm
Beschreibung:
Gupta, Shailesh
Alok Pal Jain, M. Pharma, PhD, Principal RKDF College of Pharmacy, Bhopal. Ravikan Gupta, M.Pharma, Research Scholar, SRK University, Bhopal. Dr. Shailesh Gupta, M.Pharma, PhD, Principal, Millennium College of Pharmacy and Science, Bhopal.
Alok Pal Jain, M. Pharma, PhD, Principal RKDF College of Pharmacy, Bhopal. Ravikan Gupta, M.Pharma, Research Scholar, SRK University, Bhopal. Dr. Shailesh Gupta, M.Pharma, PhD, Principal, Millennium College of Pharmacy and Science, Bhopal.
TDDS are the ideal delivery system for drug that undergo hepatic first pass metabolism. Lamivudine and Stavudune drug was successfully designed and developed by trial and error method. Formulations were prepared by employing combination of HPMCK15M, PVPK30, and EC in various ratios. From the evaluation results it was conclude that TF5 show highest release at 12 hrs. with suitable polymer ratio and penetration enhancer and it was observed that Higuchi kinetics model most suitable kinetic model for drug release from all patches.