This book explores a large population-based data set evaluating congenital anomalies as a consequence of maternal diseases. The authors review 50 years' experience in human teratology, expose weaknesses of earlier studies and offer tips for design of new ones.

uniquely large database

The Study Population and Methods.- The Hungarian Congenital Abnormality Registry (HCAR).- Results of Studies and Their Interpretation.- Certain Infectious and Parasitic Diseases.- Neoplasms.- Diseases of the Blood and Blood-Forming Organs.- Endocrine, Nutritional and Metabolic Diseases.- Mental and Behavioural Disorders.- Diseases of the Nervous System.- Diseases of the Eye and Adnexa.- Diseases of the Ear and the Mastoid Process.- Diseases of the Circulatory System.- Diseases of the Respiratory System.- Diseases of the Digestive System.- Diseases of the Skin and Subcutaneous Tissue.- Diseases of the Musculoskeletal System and Connective Tissue.- Diseases of the Urinary Tract.- Diseases of the Genital Organs.- Pregnancy, Childbirth, and the Pueperium.- Congenital Malformations, Deformations, and Chromosomal Abnormalities.- Summary of Results and Recommendations.- Association of Maternal Diseases During Pregnancy with Higher Risk of Congenital Abnormalities (CAs) in Their Children.- Associations of Maternal Diseases with Higher Risk for Pretem Birth (PB) and Low Birth Weight (LBW) Newborns.

The major objective of our studies in the last decade was a systematic analysis of maternal diseases during pregnancy to reveal their possible adverse effects on birth outcomes. The two most important factors of infant mortality were parti- larly analyzed: structural birth defects, known as congenital abnormalities (CAs) and preterm birth (PB). In general the objectives of scienti c studies might be either to test a new hypothesis or to con rm or confront previously published results. However, less frequently the authors/scientists have personal motivations determined by their professional activities. The authors of this book are practicing physicians and genetic epidemiologist who are mainly interested in the following three practical questions: 1. The possible adverse effects of pharmaceutical products. The possible t- atogenic potential of about 170 drugs has been evaluated very thoroughly using the data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA) in the last 50 years. These drugs were used to treat maternal diseases and the ndings of our population-based case-control studies will be cited in this book and are shown in the Appendix at the end of the book. However, our long experiences showed two problems in the drug teratology. In general the evaluation of clinical doses of these drugs is a particularly dif- cult challenge due to the modi cation effects of confounders. This problem motivated one of the authors to establish a new model of disaster epidemiology.