This book presents research outcomes, providing a big picture of rheumatic diseases as systemic conditions, and exploring the correlation between liver dysfunction and gastrointestinal lesions. Each chapter presents the association between major rheumatic diseases and hepato-gastrointestinal lesions, including liver and gastrointestinal involvement in lupus erythematosus, dermatomyositis, systemic sclerosis, Bechet's disease, and IgG4-related disease. The chapters on PBC-CREST syndrome and immunosuppressive agents broaden readers understanding and enable them to view the diseases from a systematic perspective. Although the disease is rare, it has attracted considerable attention as an intractable disease, and despite the severity of the symptoms, little has been written on the topic. Adopting a multidisciplinary approach, this comprehensive volume thoroughly prepares readers for research in the field of systemic diseases.Gastrointestinal and Hepatic Manifestations of Rheumatic Diseases is a valuable resource not only for hepatologists and rheumatologists, but also clinical residents and medical students.

This book presents research outcomes, providing a big picture of rheumatic diseases as systemic conditions, and exploring the correlation between liver dysfunction and gastrointestinal lesions. Each chapter presents the association between major rheumatic diseases and hepato-gastrointestinal lesions, including liver and gastrointestinal involvement in lupus erythematosus, dermatomyositis, systemic sclerosis, Bechet’s disease, and IgG4-related disease. The chapters on PBC-CREST syndrome and immunosuppressive agents broaden readers understanding and enable them to view the diseases from a systematic perspective. Although the disease is rare, it has attracted considerable attention as an intractable disease, and despite the severity of the symptoms, little has been written on the topic. Adopting a multidisciplinary approach, this comprehensive volume thoroughly prepares readers for research in the field of systemic diseases.

1. Liver involvement in rheumatic diseases.- 2. Primary biliary cholangitis is associated with CREST syndrome.- 3. De novo hepatitis B virus infection.- 4. Dermatomyositis and gastrointestinal cancer.- 5. Portal hypertension in rheumatic diseases.- 6. Gastrointestinal manifestations of systemic lupus erythematosus.- 7. Rheumatoid Arthritis and Gastrointestinal Tract Lesions (NSAID ulcers, amyloidosis).- 8. Gastrointestinal involvement of systemic sclerosis.- 9. Gastrointestinal involvement of systemic vasculitis.- 10. Gastrointestinal involvement of Behçet’s disease.- 11. Gastrointestinal involvement in IgG4-related disease.- 12. Immunosuppressive agents and intestinal involvement.