Antimicrobial resistance (AMR) is a global public health threat that needs immediate attention and action from the scientific community. This book compiles and presents the latest and most important aspects of AMR, including the biology involved, its persistence and spread, and novel approaches to tackle this threat. The book first describes the mechanisms and spread of AMR, and then discusses the various approaches and strategies for combating it. Important topics include, microbial pathogenesis, AMR traits and major mechanisms underlying drug-resistance and the emerging strategies and technologies for combating AMR. Emphasis has been given on current developments about natural products including potent phyto-molecules, antimicrobial peptides and endophytes effective against the drug-resistant microbes and target the main drug-resistance determinants (efflux pumps, biofilms, quorum sensing, plasmids, etc.) in these bacterial pathogens. Other exciting topics include applications of nanomaterials in tackling AMR and CRISPR-Cas based precise sequence-specific antimicrobials. This informative book is meant for students and researchers in basic and medical microbiology and biotechnology. It is also useful to public health professionals and industry experts involved in AMR research and related drug-designing.

Chapter 1. Antimicrobial Resistance Traits and Molecular Mechanisms of Resistance in Bacterial Pathogens.- Chapter 2. Bacterial multidrug tolerance and persisters:  Understanding the Mechanisms, Clinical implications and treatment strategies.- Chapter 3. Microbial Pathogenesis: Mechanism and recent updates on microbial diversity of pathogens.- Chapter 4. Pseudomonas aeruginosa: Pathogenic adapter bacteria.- Chapter 5. Impact of antibiotic resistance of bacteria in biofilms, microbial fuel cell: Confronting the dark box for global health threat.- Chapter 6. Plant Secondary Metabolites for Tackling Antimicrobial Resistance: A Pharmacological Perspective.- Chapter 7. Can nanoparticles help in the battle against drug resistant bacterial infections in “post-antibiotic era”?.- Chapter 8. Precise Sequence-specific Antimicrobials Based on CRISPR: Towards Prevailing Over Bacterial Antibiotic Resistance.- Chapter 9. Antibiotic resistant Klebsiella pneumoniae and targeted therapy. Chapter 10. Plant associated endophytic fungi and its secondary metabolites against drug resistant pathogenic microbes.- Chapter 11. Antimicrobial peptides as effective agents against drug resistant pathogens.- Chapter 12. Essential oils for combating antimicrobial resistance.- Chapter 13. Antimicrobial resistance and medicinal plant products as potential alternatives to antibiotics in animal husbandry.- Chapter 14. Recent updates on bacterial secondary metabolites to overcome antibiotic-resistance in Gram-negative superbugs: Encouragement or discontinuation?.- Chapter 15. Plant essential oils for combating antimicrobial resistance via re-potentiating the fading antibiotic arsenal.- Chapter 16. Bacterial Drug Efflux Pump Inhibitors from Plants.- Chapter 17. Anti-quorum sensing agents from natural sources.- Chapter 18. Plant based plasmid curing agents for combating antimicrobial resistance.- Chapter 19. Natural product as efflux pump inhibitors against MRSA efflux pumps: An Update.