Serigene LLC, Oreland, Pennsylvania, USA

This volume examines the impact of informatics tools on various areas in biopharmaceuticals by presenting in-depth analyses of emerging trends and future opportunities. It presents automation approaches for collecting and analyzing biological data and explains how to use PD biomarkers to accelerate drug development. The book also reviews a variety of novel drug discovery approaches presently used at Johnson & Johnson, and discusses the clinical successes of antibody therapeutics for treating oncology cases. In addition, it offers an integrated approach to identify relevant target genes for drug discovery and explores the application of laser microdissection in transcriptomics.

Preface Intelligent Automation James M. Dixon Neurally Inspired Algorithms as Computational Tools Mark Flynn and Garrett T. Kenyon Using Pharmacodynamic Biomarkers to Accelerate Early Clinical Drug Development Ole Vesterqvist Opportunities in CNS Drug Discovery and Development Albert Pinhasov, Anil H. Vaidya, Hong Xin, Daniel Horowitz, Daniel Rosenthal, Douglas E. Brenneman, Ewa Malatynska, Sergey E. Ilyin, and Carlos R. Plata-Salaman Clinical Success of Antibody Therapeutics in Oncology Bernard J. Scallon, Linda A. Snyder, G. Mark Anderson, Qiming Chen, Li Yan, and Marian T. Nakada Relating Target Sequence to Biological Function Greg M. Arndt Use of Protein Microarrays for Molecular Network Analysis and Signal-Pathway Profiling Katherine R. Calvo, Lance A. Liotta, and Emanuel F. Petricoin Laser Microdissection-Based Transcriptomics Using Microarrays Fredrik Kamme, Berndt Meurers, Jessica Zhu, Da-Thao Tran, Jingxue Yu, Changlu Liu, Andrew Carmen, and Bingren Hu Index