Includes cutting-edge methods and protocols

PART I: A Road Map Toward Systems Medicine
1. Systems Medicine - Sketching The Landscape

Marc Kirschner

2. Taking Bioinformatics to Systems Medicine

Antoine H.C. Van Kampen and Perry D. Moerland

3. Systems Medicine: The Future of Medical Genomics, Healthcare and Wellness

Mansoor Saqi, Johann Pellet, Irina Roznovat, Alexander Mazein, Stéphane Ballereau, Bertrand Demeulder, and Charles Auffray

4. Next Generation Pathology

Peter Caie amd David Harrison

5. Training in Systems Approaches for the next Generation of Life Scientists and Medical Doctors

Damjana Rozman, Jure Acimovic, and Bernd Schmeck

6. Systems Medicine in Pharmaceutical Research and Development
Lars Kuepfer and Andreas Schuppert

PART II: Opinions and Persepectives

7. Systems Medicine and Infection

Ruth Bowness

8. Systems Medicine for Lung Diseases - Phenotypes and Precision Medicine in Cancer, Infection and Allergy

Bernd Schmeck, Wilhelm Bertrams, Xin Lai, and Julio Vera

9. Third-Kind Encounters In Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive

Martin

Ebe

rhardt, Xin Lai, Namrata Tomar, Shailendra Gupta, Bernd Schmeck, Alexander Steinkasserer, Gerold Schuler, and Julio Vera

10. Systems Medicine In Oncology: Signaling-Networks Modeling and New Generation Decision-Support Systems

Silvio Parodi, Giuseppe Riccardi, Nicoletta Castagnino, Lorenzo Tortolina, Massimo Maffei, Gabriele Zoppoli, Alessio Nencioni, Alberto Ballestrero, and Franco Patrone

11. Neurological Diseases from a Systems Medicine Point of View

Marek Ostaszewski, Alexander Skupin, and Rudi Balling

PART III: Systems Medicine Projects and Case Studies

12. Computational Modeling of Human Metabolism and its Application to Systems Biomedicine

Maike K. Aurich and Ines Thiele

13. From Systems Understanding To Personalized Medicine - Lessons and Recommendations Based on a Multi-Disciplinary and Translational Analysis of COPD

Josep Roca, Isaac Cano, David Gomez-Cabrero, and Jesper Tegnér

14. Rna Systems Biology for Cancer: From Diagnosis to Therapy

Raheleh Amirkhah, Ali Farazmand, Olaf Wolkenhauer, and Ulf Schmitz

15. Mathematical Models Of Pluripotent Stem Cells: at the Dawn of Predictive Regenerative Medicine

Pinar Pir and Nicolas Le Novere

PART IV : Tools and M
ethodol

ogies

16.
Network Assisted Disease Classification and Biomarker Discovery

Sonja Strunz, Olaf Wolkenhauer, andAlberto De La Fuente

17. Anatomy and Physiology of Multiscale Modeling and Simulation in Systems Medicine

Alexandru Mizeranschi, Derek Groen, Joris Borgdorff, Alfons G. Hoekstra, Bastien Chopard, and Werner Dubitzky

18. Mathematical and Statistical Techniques for Systems Medicine: The Wnt Signaling Pathway As A Case Study

Adam L. Mclean, Heather A. Harrington, Michael P.H. Stumpf, and Helen M. Byrne

19. Modelling and Simulation Tools: from Systems Biology to Systems Medicine

Brett G. Olivier, Maciej Swat, and Martijn J. Moné

This volume guides readers through the field of systems medicine by defining the terminology, and describing how established computational methods form bioinformatics and systems biology can be taken forward to an integrative systems medicine approach. Chapters provide an outlook on the role that systems medicine may or should play in various medical fields, and describe different facets of the systems medicine approach in action. Ultimately it introduces tools, resources and methodologies from bioinformatics and systems biology, and how to apply these in a systems medicine project. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, and discuss experimental and computational approaches, methods, and tools that should be considered for a successful systems medicine project. Systems Medicine aims to motivate and provide guidance for collaborations across disciplines to tackle today's challenges related to human health and well-being.