This thesis studies the effectiveness of finite element macro modeling approaches in predicting the collapse resisting mechanisms such as the membrane actions. Following the validation studies on structural sub-assemblages, the alternate path mechanism is studied in 3D using nonlinear dynamic analysis. Contrary to the previous studies, this research investigates the influence of the failure-sequence in extreme initial damage scenarios. Furthermore, probabilistic characteristics of the alternate path structural response quantities as well as the ultimate load-bearing capacity of laterally restrained slabs are studied using variance-based sensitivity analysis. In particular, the influence of modeling strategies and use of substructure techniques are comprehensively discussed to develop a model quality framework for progressive collapse analysis of reinforced concrete frame structures.